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Top Stocks with Groundbreaking Potential in the DNS Manipulation and Gene-Editing Markets

Melisa R. H. Posted On June 18, 2019
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Bill Gates has known investments in the gene-editing industry.

Genetic Engineering is the field of science that manipulates DNA in order to change the gene expression. This technology is revolutionary as gene-editing and gene therapy could help people suffering from genetic disorders, as well as making humans more healthy. Applications include alleviating autoimmune disease, treatment of neurodegenerative disease, and other genetic disorders.

The field is expanding quickly, with more and more companies investing heavily into genetic engineering, especially the CRISPR/Cas9 System. CRISPR technology is considered the foremost precision gene editing tool.

Here are the top companies in the field:

👨‍⚕️ Healthcare

Agilent Technologies (A-N)
This company is a spin-off from Hewlett-Packard, which broke away in 1999. At the time, their IPO was the largest in history in Silicon Valley. They announced on June 18, 2019 the opening of a production facility in Colorado to produce nucleic acid-based therapeutics.

Agilent Technologies (A-N) — Stockchase
Agilent Technologies (A-N) — Stockchase

Opinion about A-N: It just affirmed its forecast of 5-7% annual revenue growth and steady operating margin expansion. Trades at only 22x 2025 PE.

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Biogen IDEC Inc. (BIIB-Q)
A biotechnology company that focuses on treatments for neurodegenerative, and autoimmune diseases. They recently experienced a sell-off following news that they shut down a previously promising drug for Alzheimer’s. They acquired Nightstar Therapeutics this year, who focus on adeno-associated virus based gene-therapies.

Biogen IDEC Inc. (BIIB-Q) — Stockchase
Biogen IDEC Inc. (BIIB-Q) — Stockchase

Opinion about BIIB-Q: Not impressed with products. Competitors out performing. 

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Charles River Labs Intl (CRL-N)
A preclinical and clinical laboratory company for pharmaceutical and biotech firms. They are also a contractor that offers research and development outsourcing services. They offer a genetically engineered animal models and services, as well as CRISPR/Cas9 System research.

Charles River Labs Intl (CRL-N) — Stockchase
Charles River Labs Intl (CRL-N) — Stockchase

Opinion about CRL-N: Trevor Rose’s Insights - Trevor’s most-liked answers from 5i Research CRL provides drug discovery and safety testing services and is now trading at 22.6 times' Forward P/E (historical averages range from 19x to 33x). In the last five years, revenue growth was quite healthy, averaging around 12% on average, largely driven through…

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Novartis AG (NVS-N)
One of the largest pharmaceutical companies based out of Switzerland. They are working on a drug called Kymriah that has the ability to reprogram a patient’s own immune cells.

Novartis AG (NVS-N) — Stockchase
Novartis AG (NVS-N) — Stockchase

Opinion about NVS-N: If the economy slows down, you need a good pharma stock. Novartis was stuck in a rut until the current CEO started in 2018. He made a number of key acquisitions without paying and including smaller companies (they had overpaid in the past), focusing on their most lucrative divisions: drugs to treat…

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Regeneron Pharmaceuticals Inc (REGN-Q)
A biotechnology company that has multiple key drugs, including Eylea for macular degeneration. They have one of the largest human DNA sequencing project that will help with drug discovery and development.

Regeneron Pharmaceuticals Inc (REGN-Q) — Stockchase
Regeneron Pharmaceuticals Inc (REGN-Q) — Stockchase

Opinion about REGN-Q: It's lost a third of its market cap and the selling is overdone. Now, is a buying opportunity.

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Sanofi-Aventis (SNY-N)
A french pharmaceutical company out of Paris that is the fifth largest in sales. They recently announced an over one billion dollar research deal with Denali Therapeutics for treatments for neurological and systemic inflammatory diseases.

Sanofi-Aventis (SNY-N) — Stockchase
Sanofi-Aventis (SNY-N) — Stockchase

Opinion about SNY-N: Stockchase Research Editor: Michael O'Reilly We reiterate SNY as a TOP PICK.  Recently reported earnings showed sales growth for the third consecutive quarter that exceeded 10%.  Cash reserves are prudently being drawn down to retire debt and buy back shares.  It trades at 13x earnings, 1.6x book and supports a 25% ROE. …

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Thermo Fisher Scientific (TMO-N)
A biotechnology and pharmaceutical lab equipment company. They are paying down debt and have made some acquisitions that will grow well over the next couple of years.

Thermo Fisher Scientific (TMO-N) — Stockchase
Thermo Fisher Scientific (TMO-N) — Stockchase

Opinion about TMO-N: 2023 and 2024 were challenged due to overhang with inventory. Will benefit from talk of deregulation of healthcare in the US. In spite of flat pricing for products, dividends still grow between 11-20%. Defensive, high-quality name, sleep at night, just let it ride. Yield is 0.3%. (Analysts’ price target is $643.86)

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United Therapeutics Corp. (UTHR-Q)
An American biotechnology company. Their primary drug therapy is for pulmonary disease. They acquired SteadyMed Therapeutics, a competitor with whom they were locked in a legal dispute with, last year.

United Therapeutics Corp. (UTHR-Q) — Stockchase
United Therapeutics Corp. (UTHR-Q) — Stockchase

Opinion about UTHR-Q: (A Top Pick Apr 18/24, Up 46.8%)Stockchase Research Editor: Michael O’Reilly Our PAST TOP PICK with UTHR has triggered its stop at $349.  To remain disciplined, we recommend covering the position at this time.  This will result in a net investment gain of 51%, when combined with our previous guidance.  

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Illumina Inc. (ILMN-Q)
One of the only companies that can do high volume DNA sequencing. They have brought down the cost of genetic sequencing to retail levels. They are becoming more available outside of research for commercial use in clinics.

Illumina Inc. (ILMN-Q) — Stockchase
Illumina Inc. (ILMN-Q) — Stockchase

Opinion about ILMN-Q: Likes it long term. China is 7% of their sales and has been declining the past 3 years. Has $1 billion in free cash flow a year. A high gross-margin business but it will be noisy for a while.

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Gilead Sciences Inc. (GILD-Q)
An American biopharmaceutical company that is doing research on treating cancer using DNA targets to control it. They also released great results for a HIV treatment.

Gilead Sciences Inc. (GILD-Q) — Stockchase
Gilead Sciences Inc. (GILD-Q) — Stockchase

Opinion about GILD-Q: He had owned it for 10 years at a time when it had a blockbuster drug that cured hepatitis. Gilead took profits and invested them into HIV drugs. As with other drug companies holding patents on blockbuster drugs with expiry dates, don't buy this one.

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Bristol Myers Squibb (BMY-N)
They got hit due to problems with the Celegene acquisition. Some shareholders like it, others don’t. They have an innovative pipeline and their drugs using genetic technology has performed well, as well as the biotech that will come under their wing from Celegene.

Bristol Myers Squibb (BMY-N) — Stockchase
Bristol Myers Squibb (BMY-N) — Stockchase

Opinion about BMY-N: She bought it because the industry has underperformed many years; they're facing several drugs coming off patent, but are developing new drugs they will bring to market. Trades under 9x PE and pays a 4.6% dividend. This industry will benefit greatly from AI.

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Roche Holding (RHHBY-OTC)
A Swiss multinational healthcare company. They acquired a biotech firm that does research and development for all their future products. They have some promising drugs for multiple sclerosis and cancer treatment.

Roche Holding (RHHBY-OTC) — Stockchase
Roche Holding (RHHBY-OTC) — Stockchase

Opinion about RHHBY-OTC: A month ago, they bought Carmot Therapeutics, a private clinical-stage biotech, though its drugs are only in phase 2 trials. Why did they buy this? So they can work on their own weight-loss drug, which are hot now.

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CRISPR Therapeutics AG (CRSP-Q)
One of the smaller companies developing transformative gene medications. Their gene-editing tool is used to splice DNA that has the potential of curing diseases such as Huntington’s Chorea and cancer.

CRISPR Therapeutics AG (CRSP-Q) — Stockchase
CRISPR Therapeutics AG (CRSP-Q) — Stockchase

Opinion about CRSP-Q: He sees this company mentioned in many science papers, but the stock has been a tough own. Overall, he likes it. Buy some now and more if it goes lower. How can this company keep losing money?

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